Endocrine Abstracts

Background: Type 2 diabetes mellitus (DM) is probably one of the non-communicable diseases with raised levels of glucose in the blood due to insulin efficacy. The aetiology of disease combines both genetic and lifestyle or environmental factors. (GWAS) studies have been identified CAPN10 (SNP-19), FTO (rs-9939609), MTHFR (rs1801133) and PPARG (rs1801282) genetic polymorphism with susceptibility to T2DM. The susceptibility will increase by independent risk of genetic polymorphi...

Objective: To compare FreeStyle Libre Glucose management indicator (GMI) with HbA1c and fructosamine and assess factors related to the difference.Methods: Persons with type 1 diabetes on FreeStyle Libre from a single diabetes centre whose sensor was active >70% of the time were included. Baseline characteristics, latest HbA1c, fructosamine, full blood count, total protein and albumin were collected from medical records. Ambulatory glucose profile dat...

BACKGROUND: Primary hyperparathyroidism (HPT) is increasingly diagnosed, particularly in an older population. Recent studies indicate improvement in bone mineral density (BMD) and psychological wellbeing even following treatment of apparent asymptomatic disease, supporting a lower threshold for surgical intervention. With disease being due to a solitary adenoma in most (83%) cases, we have utilised preoperative imaging together with intra-operative parathyroid hormone (IOPTH) ...